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PHYTOCHEMICAL STANDARDISATION OF KAICHUKKATTAI CHURANAM – A SIDDHA COMPOUND FORMULATION
Dr. V. Gayathri Devi* and Anitha John, Shyamala Rajkumar, B. Neethu Kannan, M. Natarajan and A. Kanagarajan
One of the major bottlenecks in the wider acceptance of herbal drugs from developing countries is the inadequacy or lack of standardization which embodies the total information and the controls that are necessary to guarantee consistency of composition of the product ensuring their quality. Working with standardized material will be helpful for scientists and doctors for obtaining genuine drug and authentically prepared compound formulations and thus standardisation research studies occupies an important place in both clinical and drug research programmes. The aim of the present study is to establish a standard for an important Siddha formulation, Kaichukkattai churanam using physico-chemical and phytochemical parameters and to detect Catechin as marker compound. The study also aims to evaluate the shelf-life period of the formulation. The physico-chemical characteristics of the drug like loss on drying at 105?C, ash value, acid insoluble ash, water soluble ash, solubility in water & alcohol and pH of water extract were determined. The fluorescent studies and preliminary phyochemical analysis were carried out. HPTLC photodocumentations, 3D densitometric chromatograms and fingerprinting profiles were documented. Catechin was isolated as marker compound from the formulation and HPTLC profile of the churanam with marker compound was documented. Shelf-life period of the churanam was determined as per ICH guidelines. The parameters obtained during the analysis of the formulation serves the purpose of reasonable and dependable standards for this formulation. Catechin was identified as marker compound and shelf-life period was found to be 1.62 years. The observations laid down a platform for the standardization and will help us to determine the genuineness of Kaichukkattai churanam. Standardization ensures the quality of medicines and gives authenticity to the medicines prepared by the manufacturers, prescribing physicians and consumers and the results obtained can be used to check and ensure the quality of the medicine.[Full Text Article] [Download Certificate]