WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Blessing Ozioma Amachukwu*, Amilo Grace I., Nancy Ibeh

ABSTRACT

It has not been established whether there are alterations in haemorheological parameters and their possible correlation with glycated haemoglobin in type 2 diabetics. Aim: To evaluate haemorheological parameters and HbA1c in type 2 diabetics for proper initiation of diagnostic protocol for diabetic subjects. Materials and Methods: Data from 237 subjects that were grouped into: (A) 59 non diabetic/non hypertensive apparently healthy controls, (B) 60 hypertensives, (C)61 Diabetics and (D)57 hypertensive diabetics was collected. Erythrocyte Sedimentation Rate (ESR) by Westergren Method, Glycosylated haemoglobin (HbA1c) by Cation-exchange method; Plasma Fibrinogen Concentration (PFC) by Clauss Method, Relative Plasma Viscosity (RPV) by Reid and Ugwu method (1987) and Fasting Plasma Glucose(FPG) by Glucose Oxidase method. Ethical approval and informed consent was sought and obtained from the hospital and subjects respectively. Anthropometric measurements were taken using standard methods. The results showed that PFC, ESR, RPV, HbA1c and BMI were significantly increased in the diabetic subjects when compared to the control subjects. PFC(mg/dl)A(380.38±21.96); B(444.73±28.21);C:(471.73±30.17); D(425.63±22.11);ESR(mm/hr):A(8.51±2.83),B(24.99±6.40),C(34.80±8.30),D(36.10±10.29);RPV:A(1.81±0.07),B(2.04±0.08);C(2.03±0.08),D(2.02±0.09);HbA1c(%):A(4.81±0.51),B(4.70±0.42)C(8.60±2.06),D(8.90±1.96);BMI(kg/m2):A,B,C,D:(25.13±3.07,32.84±2.63,34.13±2.41,31.71±3.34);respectively (p<0.001). All statistical analyses were performed using SPSS software version 20, and data were expressed as mean± standard deviation. Results compared between various groups were evaluated by Student t-test, one-way ANOVA and Bonferroni test while correlation was done using Pearson’s correlation coefficient. From this study, diabetics have haemorheological disturbances which may predispose them to cardiovascular risk. These haemorheological alterations do not predict their poor glycaemic control.