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Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
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RULE OF FIVE: THE FIVE MEN ARMY TO CROSS THE BLOOD BRAIN BARRIER FOR THERAPEUTICALLY POTENT
*Dr. Dhrubo Jyoti Sen, Kushal Nandi and Dr. Dhananjoy Saha
Drug is a chemical substance having definite structural framework, obtained either from synthetic source, semisynthetic source or natural source [animal or plant source] having capability to fit on bioreceptor platform having controlling capacity to check the malfunction of normal homeostatic cycle; whereas medicine is an application of drug into a formulation so that it can be easily administered into the body by maintaining therapeutic index to get desired pharmacological response. All drugs are chemical substance but all chemicals are not drug which is well accepted in the arena of medicinal chemistry because chemistry is a playground of functional groups which follows the four coins: how, when, why & where as medicinal chemistry runs on it’s two legs: chemistry & biology. Chemistry word is the combo effect of Chemist+Try, so try, try, try and try until you get your positive result. This positive result is based and characterized by structural network which is authenticated by spectral analysis [IR, NMR, Mass] to establish the backbone of chemical molecule. All drugs are xenobiotics [Xenus=outer source+Bioticon=active in-vivo] which are active inside the body until and unless that follows RO5 [Rule of Five]. The molecule which follows Lipinski’s rule of five can show biological action inside the living system.[Full Text Article]