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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
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DNA DEFORMATION BY ANTICANCER DRUGS THROUGH INTERCALATION
Sujata Das, *Dr. Dhrubo Jyoti Sen and Dr. Beduin Mahanti
Cancer is characterized by an abnormal and uncontrolled, division of cells, which produces tumors and invades adjacent normal tissues. Antineoplastic agents are drugs used for the treatment of cancer, malignancy, tumor, carcinoma, sarcoma, leukemia, or neoplasm. Intercalation is a special binding mode where the planar aromatic moiety of a small molecule is inserted between a pair of base pairs, causing structural changes in the DNA and leading to its functional arrest. Many anticancer drugs in clinical use interact with DNA through intercalation, which is process that starts with the transfer of the intercalating molecule from an aqueous environment to the hydrophobic space between two adjacent DNA base pairs. In general, intercalating agents are two types: monofunctional and bifunctional. Monofunctional intercalators contain one intercalating unit and Bifunctional intercalators (bis-intercalators) contain two intercalating units, normally cationic, separated by a spacer chain that must be long enough to allow double intercalation taking into account the neighbour exclusion principle.[Full Text Article]