WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

ISSN 2457-0400

Impact Factor  :  6.711

News & Updation

  • Article Invited for Publication

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  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • WJAHR: OCTOBER ISSUE PUBLISHED

    OCTOBER 2024 Issue has been successfully launched on OCTOBER 2024.

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    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

  • New Issue Published

    Its Our pleasure to inform you that, WJAHR October 2024 Issue has been Published, Kindly check it on https://www.wjahr.com/home/current_issues

  • WJAHR: New Impact Factor

    WJAHR Impact Factor has been Increased to 6.711 for Year 2024.

Best Article Awards

World Journal of Advance Healthcare Research (WJAHR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

Best Article of current issue

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Indexing

Abstract

IN SITU GELLING SYSTEM: FOR TREATMENT OF NEUROLOGICAL DISORDERS

Shreya Parkar*, Rutuja Sawant, Prajakta Kegade and Akshay Gade

ABSTRACT

Intranasal drug delivery can be visualized as the promising route for the administration of drugs as it has the potential to overcome some major limitations associated with other routes. It is one of the promising approach for the systemic delivery of drugs because concentration time profile of drugs achieved after nasal administration is often similar to that obtained after intravenous administration. Nasal administration has a drawback of poor retention time which is overcome by novel drug delivery i.e. In-situ gelling system. In-situ gelling system is a polymeric solution which can be administered in solution form, and it undergoes sol-gel phase transition into a viscoelastic gel upon exposure to physiological conditions (e.g. pH, temperature and ionic concentration). This system also has a great impact in the treatment of neurological disorders. Neurodegenerative diseases are becoming prevalent as the population ages. Preclinical reports from several researchers have proven that the delivery to the brain via the nose-to-brain route using in situ gels holds great promise. The ‘in situ gel’ system has become one of the best novel drug delivery systems by its special characteristic feature of ‘Sol to Gel’ transition. The treatment of neurological disorders require the delivery of therapeutics to the brain in appropriate amounts to elicit a pharmacological response. Nose-to-Brain delivery has emerged as a powerful strategy to overcome the BBB and deliver drugs to the brain. The present review highlights anatomy of nose, nose to brain delivery and its advances in the treatment of neurological disorders.

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