News & Updation
Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
Download Article : Click here
CIRCULATING CD34-POSITIVE STEM CELLS IN PERIPHERAL BLOOD OF PATIENTS WITH HODGKIN LYMPHOMA
Hala Ahmad*, Ghassan AlMassarani, Adnan Ikhtear, Haissam Yazigi, Reem Nadra, Suzan Samra
Hematopoietic stem cells are characterized by the properties of self-renewal and multi-lineage differentiation. Bone marrow residing stem cells are mobilized from their BM niches into peripheral blood in many pathological situations including tissue injury and systemic inflammation. Although the role of non-mutated normal stem cells in cancer progression is still under debate. Circulating normal peripheral blood stem cells may play an important role in the vascularization of the growing tumor. We assessed CD34+ cells from the peripheral blood of 15 patients with de novo Hodgkin Lymphoma using flowcytometry. We found that CD34+ cell counts and CD34+ cell percentages were significantly higher in Lymphoma patients at diagnosis than in controls. After the induction of chemotherapy, CD34+ cell count and CD34+ cell percentage levels were significantly decreased in Lymphoma patients compared with their levels at diagnosis. The mean baseline levels of CD34+ cell count and CD34+ cell percentage in Lymphoma patients who achieved complete response were significantly lower than in those who did not achieve it in response to induction treatment. We concluded that the number and percentage of circulating CD34+ cells in peripheral blood in cancer patients depend on the tumor type, and can be used as a prognostic value for complete response.[Full Text Article]