WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • Scientific Journal Impact Factor (SJIF)
  • IFSIJ Measure of Journal Quality
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database
  • Research Publication Rating and Indexing
  • Doi-Digital Online Identifier
  • ISSN National Centre
  • Zenodo Indexing
  • International CODEN Service, USA

Abstract

A NEWLY DIAGNOSED MULTIPLE MYELOMA WITH EXTRAMEDULLARY INVOLVEMENT OF THE LIVER: A RARE CASE REPORT FROM SYRIA

Firas Hussein M. D.* and Zainab Omar M. D.

ABSTRACT

Multiple myeloma is a malignant clonal proliferation of plasma cells in the bone marrow preceded by monoclonal gammapathy of undetermined significant. Extramedullary myeloma is an uncommon finding refers to the infiltration of neoplastic monoclonal plasma cells in either organs or soft tissues, with a more aggressive clinical course and poorer outcome. We herein describe a case of 65-year-old patient who presented with fatigue and severe low back pain. Ultrasound and CT scan of the abdomen showed multiple liver nodules. Biopsy of the liver nodules showed CD138 and kappa light chain-restricted positive cells consistent with extramedullary spread of multiple myeloma to the live. After 2 cycles of Cyclophosphamide, Revlimid, and Dexamethasone (CRd) the patient showed a partial response. Therefore, we decided to follow-up the same regimen. No controlled prospective studies have defined the standard treatment for multiple myeloma with extramedullary spread particularly to the liver. Treatment of multiple myeloma with extramedullary disease follows guidelines for multiple myeloma.

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