WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • Scientific Journal Impact Factor (SJIF)
  • IFSIJ Measure of Journal Quality
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  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
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Abstract

KIKUCHI-FUJIMOTO DISEASE IN A 15-YEAR-OLD GIRL: PRESENTING WITH FEVER AND CERVICAL LYMPHADENOPATHY

*Dr. Sukhneet Kaur Isher, Dr. Poonam Sahni, Dr. Kavana Son

ABSTRACT

Background: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting disorder that commonly affects adolescents and young women. Its clinical presentation frequently resembles tuberculous lymphadenitis or lymphoma, making diagnosis challenging, particularly in tuberculosis-endemic countries. Case Presentation: A 15-year-old girl presented with fever and left-sided cervical lymphadenopathy. Laboratory investigations showed mild anemia, leukopenia, elevated ESR, normal CRP, and negative infectious work-up for dengue, malaria, typhoid, and chest radiography. Fine needle aspiration cytology suggested granulomatous lymphadenitis with no acid-fast bacilli identified. Because of persistent lymphadenopathy, an excision biopsy was performed. Histopathology demonstrated necrotizing lymphadenitis with abundant karyorrhectic debris, absence of well-formed granulomas, giant cells, Reed-Sternberg cells, and cellular atypia. We considered Kikuchi-Fujimoto disease as an important differential diagnosis and advised immunohistochemistry (IHC). The IHC profile confirmed the diagnosis of KFD. Conclusion: This case highlights the importance of meticulous histopathological examination followed by targeted immunohistochemistry in establishing the diagnosis of KFD and avoiding unnecessary treatment for tuberculosis or lymphoma.

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