WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Adwaa Fadil Saleh, *Maan Hasan Salih, Rafea Zaidan Al-sugmiany

ABSTRACT

Background: The biggest challenge that humanity has faced since 2019 is the spread of the Covid 19 pandemicworldwide. The researchers focused more on the mechanism by which the spike (S) protein of the virus bindingwith the ACE2 receptor and then enters the host. Methodology: In the current study, 124 individuals of COVID-19 patients were classified into three groups, Mild (N=39), Moderate (=40), and Sever (N=45) cases. We used anamplification refractory mutation system (ARMS-PCR) for ACE2 (rs6629110 and rs2106806) genotyping.Results: As the results show, there is no significant difference in the genotype distributions of ACE2 (rs6629110and rs2106806). However, in over dominant models of ACE2 (rs6629110) CT genotype we indicate a relativeincrease in the value of the added ratio in moderate cases with OR 1.2879 (95%) CI = (0.5235 to 3.1683), p <0.5817 and with OR 1.4006 (95%) CI = (0.5813 to 3.3743), p < 0.4527 in severe cases. Also, the codominantmodel in ACE2 rs2106806 (AA) genotype was observed a relative increase in the value of the added ratio inmoderate cases with OR 1.9286 (95%) CI = (0.7020 to 5.2984), p < 0.2028 and with OR 2.4545 (95%) CI =(0.8940 to 6.7388), p < 0.0814 in severe cases. Conclusions: This study has found that generally an associationbetween over dominant models of ACE2 (rs6629110) CT and increased symptoms of illness, but not significantly.Also findings the association between codominant models of ACE2 (rs2106806) AA and increased symptoms ofillness, but not significantly. However, to prove the theory, we need more future studies with a larger number ofvolunteers, preferably from different populations. .

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