WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
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  • IFSIJ Measure of Journal Quality
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Abstract

MISMATCH REPAIR AND P53 STATUS IN ENDOMETROID TYPE OF ENDOMETRIAL CARCINOMA, ASSOCIATION WITH CLINICOPATHOLOGICAL PARAMETERS IN IRAQI PATIENTS

Dr. Nabaa Abdul Kareem Yonus*, Dr. Saba Adnan Hasan

ABSTRACT

Background: Endometrial carcinoma is a common gynecological cancer and represents a major cause of morbidity and mortality among women.Research Objectives• Prevalence of MMR and P53 among Iraqi patients.• Clinicopathological correlation.Material and Methods: Cross sectional analytical study of surgically treated women with endometroid type of endometrial carcinoma. Statistical analysis was performed using IBM SPSS Statistics version 23. Continuous variables were summarized as mean ± standard deviation (SD) for the overall study population and as median with interquartile range (IQR) for group comparisons. Result: No statistically significant associations were observed between MMR status and other clinical and pathological variables (p > 0.05).No statistically significant associations were identified between p53 expression status and any of the studied clinicopathological variables (p > 0.05). Conclusion: MMR deficiency was identified in a substantial proportion of Iraqi patients, with MLH1/PMS2 co-loss being the predominant pattern. whereas aberrant p53 expression showed no significant association with the clinicopathological parameters examined. These findings provide preliminary molecular data on endometrioid endometrial carcinoma in the Iraqi population and support further investigation of MMR and p53 abnormalities in larger studies.

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