WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Inaam Ghanim Ibrahim AL-Abady, Zainab Issam Ali AL Hatim

ABSTRACT

Background: Beta- thalassemia major is a genetic disease characterized by formation of little or no beta-globin chain, leading to premature death of red blood cells and ineffective erythropoiesis. The existence of a high incidence of thrombo-embolic events, led to the identification of a hypercoagulable state in these patients. Aims: To evaluate D-dimer, fibrinogen levels in B-thalassemia major patients, and to correlate these parameters with platelets count, splenectomy and complication of disease. Methods: A case-control study conducted at "AL-Hadbaa" Blood & Bone Marrow Transplant (BMT) Hospital in Mosul city in Iraq from March to August 2025, including (100) patients diagnosed with β-thalassemia major and 50 age and sex-matched healthy control were compared as regards complete blood count, prothrombin time, activated partial thromboplastin time, fibrinogen, D.dimer and s. ferritin. Result: The mean of prothrombin time and activated partial thromboplastin time, D. Dimer were significantly higher in patients with β-thalassemia major in comparison to control with p-value of (0.000),)(0.000), and (0.000) while mean fibrinogen was significantly lower in patients than control group (p-value 0.027). A significant correlation between high platelets count and PT, fibrinogen and D-dimer were noted with p-value (0.044), (0.029), and (0.004) respectively. Mean Fibrinogen and D-dimer were significantly higher in cases with splenectomy than those whom not splenectomized at p-value of (0.001and 0.007) respectively. A significant (p=0.002) and strong positive correlation (r=0.309) was noted between time after starting blood transfusion (years)and fibrinogen level. Conclusion: The correlation between high platelets count and some of hemostatic parameters were significant as there is evidence that increased platelets count associated with hypercoagulable state.

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