WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
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Abstract

GUT MICROBIOTA-MEDIATED DRUG METABOLISM: IMPACT ON PHARMACOKINETICS AND PERSONALIZED THERAPEUTICS

Dr. Nidhi Chauhan*, Mr. Ghanchi Husen Hamidbhai*, Mr. Vijay Oza, Mr. Zarakh Saad Saeed Hashan, Mrs. Niharika Patel

ABSTRACT

The gut microbiota plays an important role in drug metabolism and pharmacokinetics by influencing drug absorption, bioavailability, and toxicity through various microbial enzymatic reactions.[1–3]. Increasing evidence suggests that microbiota-mediated drug metabolism contributes significantly to interindividual variability in therapeutic response and adverse drug reactions.[4,5] Gut microorganisms can activate prodrugs, inactivate therapeutic agents, generate toxic metabolites, and regulate host metabolic enzymes.[6,7] Advances in pharmacomicrobiomics and microbiome research have highlighted the importance of integrating microbial profiling into personalized medicine.[8,9] Understanding drug–microbiota interactions may improve therapeutic outcomes, minimize adverse effects, and facilitate precision-based pharmacotherapy.[10]

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