WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • Scientific Journal Impact Factor (SJIF)
  • IFSIJ Measure of Journal Quality
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
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  • International Scientific Indexing ( ISI )
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  • Zenodo Indexing
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Abstract

EXO-SCAFFOLDS: REGENERATING PERIODONTIUM

Aishwarya Agale*, Dr. Snehal Kale, Dr. Motilal Jangid, Dr. Roshani Thakur, Dr. Ujjwala Makne, Dr. Dipali Nikam

ABSTRACT

The periodontium is a complex, dynamic entity comprising a harmonious union of hard and soft tissues that envelop and stabilize teeth. This intricate relationship between hard and soft tissues enables the periodontal system to effectively absorb and dissipate masticatory forces, thereby ensuring its structural and functional integrity. The regeneration of damaged periodontal tissues, remains a significant hurdle in periodontitis treatment. The ultimate goal of periodontal therapy is to achieve periodontal regeneration. Consequently, there is a pressing need to explore novel therapeutic approaches. Exosomes, which are derived from stem cells, have emerged as a promising adjunct to stem cell therapy, exhibiting comparable therapeutic outcomes. These nanoscale vesicles have demonstrated remarkable potential in modulating immune responses, mitigating inflammation, regulating microbiota, and promoting tissue repair, with particular efficacy in rejuvenating periodontal tissues. Moreover, the integration of exosomes with biomaterial scaffolds in periodontal tissue engineering plays a vital role in the treatment of periodontal defects, from scaffolds that create the microenvironment and deliver signaling molecules.

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