WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
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Abstract

NANO HYDROXYAPATITE: BONE GRAFT INNOVATION

Dr. Snehal Kale*, Dr. Motilal Jangid, Dr. Roshani Thakur, Dr. Ujjwala Makne, Dr. Dipali Nikam

ABSTRACT

Nanocrystalline hydroxyapatite (n-HA) is the primary inorganic constituent found in hard tissues.. Thedevelopment of commercial synthetic analogues, known as ‘biomimetic’ materials, has garnered significantattention due to their ability to closely replicate the physicochemical characteristics of biological apatitecompounds. With enhanced osseointegrative properties, nano-hydroxyapatite (n-HA) stands out as a promisingclass of bone graft materials, offering improved compatibility and functionality for regenerative applications.Nano-hydroxyapatite (n-HA) exhibits a strong affinity for bone tissue, where it promotes bone healing bystimulating osteoblast activity and enhancing the expression of local growth factors. Clinical studies usingnanocrystalline hydroxyapatite bone grafts in the treatment of human periodontal intrabony defects havedemonstrated significant benefits, including reductions in pocket depth and osseous lesion depth, as well asstatistically significant gains in clinical attachment levels. n-HA presents multiple benefits for periodontal tissueregeneration, such as low patient morbidity, excellent biocompatibility, and a non-toxic profile. These qualitiesmake it a highly favorable option for promoting effective and safe tissue repair.

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