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EFFECT OF IONIZING RADIATION (X-RAYS) ON PERIPHERAL BLOOD T-CELL SUBSETS IN INTERVENTIONAL ANGIOPLASTY PROCEDURE WORKERS
*Dr. El-Shanshoury H. and Amaal A. Tawfik
Angioplasty is a procedure using x-ray imaging equipment to open stenosed or occluded blood vessels. Ionizing radiation can be considered as a ‘two-edged sword’ in that it may lead to immune suppression or overreaction. The specific response of the immune system is based on the action of T-cells which are the lymphocytes developed in the thymus. The present study included forty five workers divided into 3 groups fifteen each. Group 1 is control and the other two are members in catheter lab and vascular surgery departments. Groups 2 and 3 were provided with personal dosimeters (TLD-100) to collect and estimate their exposure doses to x-ray for three months duration. Percentage of CD4 in groups 2 and 3 (workers with occupational period < 5 years and those with occupational period > 5 years respectively) increased highly significantly in compared to control group at (P-value <0.001). On the other hand, there is no statistically significant difference between the means of CD8+ groups’ percentage at p-value of 0.340. So, there is no influence of the occupational periods on CD8+ counts of workers. The same description is on CD4/CD8 ratio where there is no effect of the occupational period at P-value of 0.08. This indicates that increasing in occupational period may induce changes in the immune system gradually and more investigations are needed to prove that.[Full Text Article]