WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Dr. Ahmed Dawood Salman*, Dr. Omar Khalid Jaleel, Dr. Muhannad Muwafaq Almukhtar, Dr. Ali Shawqi Saadoon, Dr. Marwan AlMashhadani

ABSTRACT

Background: The surgical procedures are associated with perioperative blood loss. Caesarian section is a common operation associated with blood loss of around 600-800 ml, tranexamic acid as antifibrinolytic agent blocks lysine-binding site on plasminogen molecule and it is used to decrease bleeding-related morbidity and mortality in pregnant women. Aim of the study: Assess the role of prophylactic tranexamic acid in reducing intraoperative blood loss in Cesarean section under general anesthesia. Patient and Methods: One hundred ASA class II adult consented female patients, scheduled for elective C-section were blindly randomized into two groups to receive either (group A) 10 ml of normal saline as Placebo or (group B) intravenous 10mg/kg tranexamic acid 15 min before anesthesia. All patient's total blood loss was measured and recorded perioperatively. Result: The tranexamic acid significantly reduced the quantity of total blood loss, 625 ± 25.4 ml in study group as compared to 744.72 ± 55.1 ml in the control group (P<0.01). Conclusion: The prophylactic administration of Tranexamic acid had statistically significant in reducing the blood loss without any adverse effects during the study time.