WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
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  • IFSIJ Measure of Journal Quality
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
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  • Zenodo Indexing
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Abstract

AETIOLOGICAL INSIGHTS INTO RENAL CALCULI

*Mijanur Rahaman, Eakub Ali, Syeda Nishat Fathima

ABSTRACT

Renal calculi develop due to a complex interplay of metabolic, dietary, genetic, environmental, and lifestyle factors that disrupt the balance of stone-forming and inhibitory substances in urine. Key contributors include low fluid intake and dehydration, supersaturation of urine with calcium, oxalate, or uric acid, and deficiencies in natural inhibitors such as citrate and magnesium. Comorbid conditions like diabetes, metabolic syndrome, and hyperparathyroidism, along with infections, certain medications, dietary excesses, sedentary lifestyle, and climatic factors, further increase stone risk. Genetic predisposition and family history also play a significant role, highlighting the multifactorial nature of nephrolithiasis. Effective prevention and management require addressing hydration, diet, physical activity, and underlying metabolic or systemic conditions to reduce stone formation and recurrence.

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