WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2457-0400

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Indexing

Abstract

EFFECTIVENESS OF METHOTREXATE IN THE TREATMENT OF GRANULOMATOUS MASTITIS

*Dr. Kawa Mohammed Mawlood Bajalan, Dr. Mohammed Majeed Abdulwahid, Dr. Luqman Mohammed Azeez

ABSTRACT

Background: Granulomatous mastitis is an uncommon, benign inflammatory disease of the breast. Clinically and radiologically, granulomatous mastitis can mimic a tumor. Various treatment modalities are available in clinical practice including medical and surgical interventions. Aim of the study: To assess the efficacy of the use of combined therapy of methotrexate and steroids in the management of granulomatous mastitis in whom steroid monotherapy failed or poorly responded. Patients and methods: For this retrospective study, data from 19 patients with biopsy-proven granulomatous mastitis were assessed. Demographic features clinical characteristics and course of the patients were obtained from medical records. Results: Following 3-month methotrexate therapy, 12 patients showed (63.2%) complete, 4 patients (21.1%) partial response, and the treatment had no effect in 3 patients (15.8%). No adverse effect was documented because of the methotrexate therapy. Conclusions: combination therapy of methotrexate and steroids in patients not responding to steroid monotherapy or having adverse effects should be regarded as alternative therapy instead of surgical treatment.

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