WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Nagham Ismael Ibrahim, Farah Ramzi Shareef and Ameera Ahmed Mohammed

ABSTRACT

Background:The incidence of missed abortion cannot be accurately estimated because the incidence ofconception is unknown. Angiopoietin 1 is a member of the growth factor family and is an angiogenic protein. Theplacental syncytiotrophoblasts and mesenchymal cells both release it, as a result its alternating levels can paly arole in detecting abortion. Objectives: Is to determine whether serum angiopoietin 1 is a useful indicator ofmissed abortions in the first trimester among pregnant ladies in Mosul City. Methods: The study is a descriptive, case control study, conducted in the department of Gynaecology and Obstetrics of Al Khansa’a Teaching Hospital in collaboration of the laboratories department of the hospital between the 11th of April 2024 to the end of January 2025. The questionnaire was divided into two main sections. The first section provides demographic information about the study participants. The second section covers laboratory findings of the study participants. Results : Thestudy included 100 first trimester pregnant women, whose pregnancy also confirmed by ultrasound. Of them; 50women with confirmed ultrasound of missed abortion (the cases) and 50 women with confirmed ultrasound ofviable fetuses (the controls). Furthermore; the mean age of the study participants are 24.53 ± 5.26 years, while; themean of gestational ages of the study participants are 8.97 ± 1.37 weeks. Additionally; statistically significantdifference between the study groups found regarding gra vity (more gravity found among cases group), parity(more parity among cases group), abortion (more abortion among cases group). It’s evident that angiopoietin 1 isstatistically significant different between cases and controls with higher mean levels amon g controls group. Fromthe other hand; no statistically significant difference is found regarding mean of fibrinogen, APTT, PT and INR.Lastly; the cut off point of ≤ 1.002 can detects viable fetus from missed abortion (total area of 0.037, P value of0.00 1), with sensitivity of 92 %, specificity of 90 %, positive predictive value of 90.1 %, negative predictive valueof 91.8% and total accuracy of the test of 91 %. Conclusion: According to the current study, pregnant womenwho have missed an abortion have c onsiderably lower serum levels of angiopoitin 1 than those in a normal viableand matched gestation pregnancy with high sensitivity and specificity. It might suggest that it plays a part in thepathophysiology of missed abortions.