WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Dr. Lina Ahmed Ridha*, Dr. Aimen Hameed Latef and Dr. Ahmed Al-Mantafji

ABSTRACT

Background: Endotracheal intubation is the prominent cause of airway mucosal injury which results in the postoperative sore throat (POST), In spite of it is a minor complication, if left without management, it produces significant dissatisfaction to the patient. Aim of the study: To assess the efficacy of ketamine nebulization in decreasing POST incidence with Endotracheal intubation. Patient and Methods: 70 patients undergoing General Anesthesia with endotracheal intubation participated in this prospective, randomized, placebo-control, and double-blind study. Patients were randomized into two groups, Group One were given ketamine 50 mg (1.0 ml) with 4.0 ml of normal saline nebulization, while Group 2 were given normal saline nebulization (5.0 ml) for 15 min both, POST assessment was started once patients had reached the recovery room at 0, 2, 4, 6, 12, and 24 hours after extubating, POST was graded on a four-point scale (0,1,2,3). Results: The incidence and severity of POST were significantly less in the ketamine group with time interval in compared with the 2nd group. There was a statistically significant lowering in the incidence of POST in the ketamine group when compared to saline, at 2, 4, 6,12, and 24 h postoperatively (P < 0.05*), The severity of sore throat was also higher in the saline group when compared to ketamine at all time interval. Conclusion: Preoperative ketamine nebulization effectively reduced the incidence and severity of POST, with no adverse effects.

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