WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

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  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • WJAHR New Impact Factor

    Its our Pleasure to Inform you that WJAHR Impact Factor has been increased from  4.897 to 5.464 due to high quality Publication at International Level

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    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

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Best Article of current issue

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Indexing

Abstract

CASE SERIES OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

Dr. Aamir Malik* and Neha Sharma

ABSTRACT

Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a hyper-inflammatory syndrome characterized by fever, hepatosplenomegaly, bone marrow, skin, and central nervous system infiltration. Incidence of HLH is 1 per 50,000 live births worldwide. In this case series, we present 13 cases of HLH in adults; their presentation, course, and outcome over a period of three years Materials and Methods: We retrospectively looked at 13 cases of HLH who presented to our hospital. Data was collected from computerised electronic medical records in addition to referring to hard copies of patients’ records. The median age at diagnosis was 42.5 years (age range 25 years–60 years). Diagnosis was based on fulfilling clinical and laboratory criteria. Results: All patients initially presented with unremitting prolonged fever, splenomegaly and bicytopenia or pancytopenia. Blood investigations showed elevated ferritin (n = 13), elevated liver enzymes[6] and high lactate dehydrogenase (LDH),[8] hypertriglyceridemia and hypofibrinogenemia in (n = 10). The main causes were Epstein barr virus,[5] malignancy(b cell lymphoma),[3] abdomen tuberculosis[2] Conclusions: HLH is a rare but rapidly fatal disease and may present in a wide range of different presentations. A persistent and prolonged fever with associated progressive abdominal distention (hepatosplenomegaly) and cytopenias over an acute phase should raise the suspicion of HLH. Accordingly, early diagnosis and prompt aggressive treatment are vital for patients’ survival and favorable outcome.

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