WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

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Abstract

CARDIOVASCULAR STUDY OF OXIDATIVE STRESS AND ECG WAVE PATTERN IN OBESE AND NON OBESE ADULT FEMALE IN EKPOMA, NIGERIA

*Aigbiremolen A. A., Edebiri O. E., Akhile A. O., Odigie O. M. and Aloamaka C. P.

ABSTRACT

The study assessed oxidative stress biomarkers enzyme activities, side by side a recorded surface ECG on non obese and obese amongst female adult to determine changes in ECG patterns. Twenty (20) consenting adult female subjects were recruited from Ekpoma metropolitans, Edo State. Five milliliters (5 ml) of venous blood was drawn from consenting participants and placed in a lithium heparin sample bottles. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for oxidative stress biomarkers concentrations. Oxidative stress biomarker (catalase) activities in Obese and non obese adult females were significantly different p<0.05 and greater in obese. The mean value catalase of Obese was (84.99±1.235) and Non obese (34.82 ± 1.590). Superoxide Dismutase(u/l) 0.4240± 0.008327and 0.2010± 0.01810 significantly p<0.05 greater in obese. Glutathione peroxidase(u/ml) 7.509± 0.3769 and 3.389± 0.1967 significantly greater p<0.05 in obese. The overall findings shows that oxidative stress is prominent in obese as evident in the higher values of catalase, Superoxide Dismutase biomarker and Glutathione peroxidase enzyme activities compared to non obese.

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