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Abstract
CLINICAL AND HISTOPATHOLOGICAL STUDY OF KERATINIZING AND NON-KERATINIZING NASOPHARYNGEAL SQUAMOUS CELL CARCINOMA
*Maha Kamil Luaibi and Dr. Mohammed Radef Dawood
ABSTRACT
Background: nasopharyngeal carcinoma (NPC) is unique in its epidemiologic pattern. It is common in certain ethnic groups; Epstein Barr Virus infection has been proposed as a risk factor but per-sue it is not sufficient to cause malignancy. Other co factors like genetic and environmental susceptibility may contribute in the carcinogenesis of NPC. Aims: To study various presentations of NPC and its relation with disease severity and date of diagnosis. To analyze the correlation between risk factors and the disease entity. To assess the relative frequency of histopathological results. Patients and Methods: this is combined prospective and retrospective study of 25 patients with confirmed NPC between 2017 and 2020 conducted in Al Yarmouk Teaching Hospital, all patients included fulfill the questionnaire sheet with assistance of radiological and histopathological department, and we classify them according to WHO classification and AJCC staging system and investigate the finding with various parameters. Results: in current study we found that 18 (72%) of cases were male patients and 7 (28%) were female, the most common age presentation was in the 7th decade (9 patients) with second peak between 20-29 years old, the most frequent clinical presentation in general was neck mass in 20 (80%) of cases, 21 (84%) of patients diagnosed with NKSCC and the remaining 4 (16%) patients had KSCC, advanced disease presented in 18 (72%) of cases while only 7 (28%) were in early stages. Conclusions: the present study reveals a bimodal age distribution at (60 years and more) in 36% of patients, the next frequently affected age group was (20-29) year by 20% of patients, male is more common affected than female in a ratio of 2.5:1, most common histopathology was NKSCC, there is a significant relation between neurological symptoms and advanced stage of disease. Also a significant relation between initial otological presentation and long interval till proper diagnosis.
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