WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

ISSN 2457-0400

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

THE EFFECT OF SYSTEMIC ISOTRETINOIN ON FERTILITY IN MALE PATIENTS WITH ACNE VULGARIS

Noura Ali*, Mohamad Ismaiel and Faisal Radwan

ABSTRACT

Background: Acne vulgaris is a common dermatological problem that affects males and femals in the adolescent period and early adulthood. Isotretinoin is the treatment of choice for moderate to severe cases of acne vulgaris, as it provides complete cure with minimal scarring. Males receiving isotretinoin are always concerned about its adverse effects, especially on their fertility potential. Objective: To study the effect of systemic isotretinoin on semen parameters of male patients treated for acne vulgaris. Materials and Methods: This study was carried on 30 male patients with acne vulgaris presented to the Dermatology Clinic, Tishreen University Hospital, Lattakia. A dose of 0,5 mg/kg of systemic isotretinoin was given to all patients over a period of 6 months. Semen analysis was done for all patients before and after 6 months of use. Results: After the course of systemic isotretinoin, a statistically significant increase in sperm concentration (million/ml), total concentration (million) and progressive sperm motility % was observed, without any statistically significant increase in morphologically normal sperm% after isotretinoin use. Conclusion: Systemic isotretinoin in acne vulgaris is a safe modality of treatment with no harmful adverse effects on semen parameters, after 6 months of use.

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