WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Zeinab Saker* and Ruba Salman

ABSTRACT

Background: Type 2 diabetes mellitus(T2DM) represents a disorder of glucose metabolism that is characterized by hyperglycemia and insulin resistance. Liver involvement in T2DM is recognized in the form of non-alcoholic fatty liver disease (NAFLD) which can range from simple steatosis to liver cirrhosis. Objective: The aim of this study was to determine the prevalence of liver transaminase disorders in T2DM patients, and the association with glycemic control. Patients and Methods: A Descriptive Observational Cross Sectional study was conducted for the period one year (2021 –2022) at Tishreen University Hospital in Lattakia-Syria. The study included all T2DM patients older than 18 years with a duration of diagnosis disease longer than 6 months. Alanine transaminase(ALT) and Aspartate transaminase(AST) were measured for all patients with abdominal ultrasound. Results: The study included 189 patients with T2DM. Fatty liver disease was detected in 72 cases (38.1%) which was associated with elevated levels of ALT in 60 cases (83.3%) and AST in 24 cases (33.3%). Elevated levels of ALT were associated significantly with increasing body mass index BMI, fasting plasma glucose FPG, glycosylated hemoglobin HbA1c, total cholesterol TC, triglyceride TG, low-density lipoprotein LDL, and decreasing high density lipoprotein HDL (p

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