WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Abedrazak Mohammad Ibrahim*

ABSTRACT

Background: Vitiligo is a stigmatizing disorder that can cause cosmetic disfigurement and cause severe psychological issues in daily life. About 0.5% of the world's population experiences it, and males experience it just as frequently as girls. The UV radiation's well-established immune-modulatory effects may account for the stability of both local and systemic aberrant immunological responses. Aim of the study: Toohedthsfeshhassha htth shadta BVrBamtassha sfhesehtsadtarmsmomeda.aPatients and Methods: This prospective case-series study includes 50 patients with generalized Vitiligo who attending the Dermatology Unit at Al-Salam Teaching Hospital. After examination, the objective of the study was discussed with the patients and verbal consent was taken for the participation in the study. The patients were referred to the researcher private clinic for the treatment. Therapy was administered three times per week on nonconsecutive days and a standard initial dose of 280 mJ/cm2 was started in all patients and the study period extended for 12 months; from June 2021 to May 2022. Results: The mean age is 19.4± 3.2 years. Seventeen patients are males and thirty three are females with a Female: male ratio is 1.94:1. Most of males and female are below the age of 20 years; 29.4% and 35.3% of males are at the age group (?10 years) and (11-20 years) respectively. The females at the (?10 years) age group are 21.2% and at the (11-20 years) age group are 51.5%. The mean duration is 9.4±1.1 years with a range of 0.5-17 years. 7(14.0%) of the patients have excellent response, 19(38.0%) good response, 14(28.0%) moderate response, while 10(20.0%) have poor response. Most of the patients 45 (90.0%) did not report any side effect. The recorded side effects are mild erythema is 2(4.0%), pruritis 1(2.0%), burning pain 1(2.0%), and xerosis 1(2.0%). Conclusion: Conclusion: Many patients had re-pigmentation quickly as a result of this therapy regimen. This data supports earlier studies by showing that narrow-band UVB is an effective and well-tolerated treatment for vitiligo.

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