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Abstract
THE UPSURGE IN THE FIELD OF PHAGE -BACTERIA- EUKARYOTIC ASSOCIATION BESIDES THEIR IMPACT ON HUMAN HEALTH ALONG WITH DISEASE- THERAPEUTIC IMPLICATIONS WITH ESCALATING ANTIBIOTICS RESISTANCE-A MINIREVIEW
*Dr. Kulvinder Kochar Kaur, Dr. Gautam Nand Allahbadia and Dr. Mandeep Singh
ABSTRACT
Having reviewed the role of gut microbiota(GM)in human obesity, type 2 Diabetes mellitus(T2DM), Non alcoholic fatty liver disease(NAFLD), metabolic syndrome(MetS) and further extension to development of neuropsychiatric diseases(NPD), here we did a minireview regarding gut virome and impact of triad symbiosis. An escalating research divulges the individuality along with in general astonishing modes by which bacteriophages that are viruses that have become specialized with regards to bacteria, possess the capacity of impacting human health along with diseased stages. This might take place directly by influencing their host bacterial ecology via top down pressure or through greater indirect means inclusive of impacting human body metabolism or immune system. These crosstalk of microbes possess the capacity of impacting health along with disease by affecting the local milieu or via body’s distant organs/ systems. Thus we carried out a minireview with the utilization of using the pubmed, Web of Science, Medline, Embase, Cochrane reviews, and Google Scholar, Search engine with the MeSH Terms; Gut Microbiota(GM); bacteriophage; human health; immune system; antibiotics resistance; triad symbiosis; genetic engineering from 2010 onwards till date in 2022 we found a total of 6000 articles out of which we selected 51 articles for this minireview. Thus we describe the present insight with regards to impacting human health with regards to tripartite symbiosis with the bacterial as well as human hosts. Furthermore, the clinical applications in this era of antibiotics resistance as well as clinical trials in lung infections is detailed.
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