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EFFECT OF (HYOSCINE BUTYLBROMIDE) ON THE DURATION OF THE FIRST STAGE OF ACTIVE LABOR IN FULL TERM PREGNANT WOMEN
*Alagha Alaa, Mohammad Basel and Issam Aldali
Background: Prolonged labor contributes to increased perinatal and maternal morbidity. Active management of labor reduces the number of cesarean deliveries, the number of prolonged labor, and the duration of labor without having any adverse effects on the mother and the fetus. Objective: The aim of this study was to determine the effect of HBB on the duration of the first stage of active labor in full term pregnant women. Methods: The study was a Randomized Control Trail carried out at Tishreen University Hospital in Lattakia-Syria during the period between(2021-2022). study included 143pregnant women in full term with spontaneous onset of labor. The patients were divided into two groups, study group: 73 pregnant women, They received (20mg of hyoscine butylbromide diluted in 9 ml of saline solution) slowly intravenously. Placebo Group: 70 pregnant patients, received placebo(10 mls of intravenous normal saline). The mean duration of the first stage of active labor was compared between the two groups. Results: The observed mean duration of the first stage of labor was significantly shorter (P = 0.002) in the Hyoscine butyl-bromide group (4.36±2.4 h) than in the Placebo group (5.49±2.8 h). There was no significant difference between the two groups in the mean duration of the second and third stages of labor (28.9±10.8 vs. 32.1±11.3 min, p=0,3. And 6.2±2.03 vs. 6.7±3.2 min, p=0,4, respectively). The median APGAR scores at the 1st and 5th minutes were also comparable (8.4±0.9 vs. 8.6±1.1, p=0.1. And 9.3±0.4 vs. 9.5± 0,3, p=0.2, respectively). the side effects of HBB were seen in the two groups, but difference between the both groups was not statistically significant (p value> 0.05). Conclusion: HBB reduced the duration of first stage of labor in pregnant women without adverse maternal and neonatal complications. It is recommended that HBB to be given to women in active phase of labor to reduce the incidence of prolonged labor.[Full Text Article]