WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

IN VITRO AND IN VIVO STUDY OF ANTI-DERMATOPHYTIC ACTIVITY OF THYMOL, CARVACROL, EUGENOL AND MENTHOL

Imane Jabeur, Dr. Abdelilah Dassouli, Chaimae Imane Sennouni, Dr. Mounia Oukhouia, Houda Hamdani, Dr. Adnane Remmal*

ABSTRACT

The aim of this work is to test the anti-dermatophytic activity of some Major Compounds (MCs) of Essential oils (EOs) (eugenol, menthol, thymol and carvacrol) against three dermatophytes isolated from clinical cases of dermatophytosis (Trichophyton violaceum, Microsporum canis and Trichophyton mentagrophyte). The anti-dermatophytic activity of MCs was tested in vitro by using: the broth dilution method and the agar dilution method in order to determine the minimal inhibitory concentration (MIC) and the minimal fungicidal concentration (MFC). The activity was then tested in vivo by using an experimental model of induced dermatophytosis in rabbits. Carvacrol and thymol revealed an anti-dermatophytic effect against all tested with (MIC) and (MFC) values between 250 ?g/ml and 1000 ?g/ml. The sporulation of target dermatophyte species decreased with increasing concentrations of MCs. As the most effective MC, thymol has shown a great effect on the treatment of skin dermatophytosis in rabbits caused by T. violaceum and M.canis. A significant reduction of the number of colonies sampled from the infected skin was observed at 1000 ?g/ml compared to untreated control rabbits. These results demonstrated that thymol and carvacrol are potential sources of natural fungicides and could be used as an alternative to chemical anti-dermatophytic drugs.

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