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SERUM LEVEL OF 25-HYDROXYVITAMIN D IN PREGNANCY, AND ITS CORRELATION WITH SPONTANEOUS ABORTION
*Afnan Alwan Laftah and Prof. Dr. Basil OM Saleh
Background: Vaginal bleeding before 20 weeks of gestation occurs in up to 20% of pregnancies, and half of these cases will have a spontaneous abortion. Vitamin D deficiency is common in women of reproductive-age and pregnant women. Aim of study to Measurement of serum level of 25-hydroxyvitamin D (25OHVD) in women spontaneously aborted during early pregnancy and women with successful ongoing pregnancy to identify its association with spontaneous abortion and to assess the correlation of 25OHVD level with maternal ages, their body mass index and gestational ages. Method: This case-control study included 82 women; 41 pregnant women suffered from abortion as patient group and 41 pregnant women presented with ongoing pregnancy as control group. Aborted women were sub classified according to number of their abortions into; first and recurrent abortion women. Women with uterine diseases or abnormalities, immunological diseases, endocrine disorders such as diabetes and thyroid diseases, history of infections, consanguinity, family history of genetic disorders, and smoker patients were excluded from this study. Both groups' participants were aged between 18 and 35 years old, and none of them had taken vitamin D supplements for the last three months prior to pregnancy. Body mass index (BMI) was calculated from weight and height and serum total 25OHVD was measured by using enzyme linked immunosorbent assay (ELISA) technique. Results: The highest proportion of study participants in patient and control groups was aged ? 25 years (68.3% and 53.7% respectively). The results of study revealed that 36.6% of patient women were of normal weight, 39% were overweighed, and 24.4% of them were obese. The results also showed that mean ± SD value of 25-hydroxyvitamin D (25OHVD) levels was significantly lower in aborted women group than in control group (p <0.05). In addition, the mean value of 25OHVD levels of patient women with recurrent abortions was significantly lower than that of first time abortion (p <0.05). There was no significant correlation between 25-hydroxyvitamin D level and each of age, body mass index, and gestational age in both patients group and control group. Conclusion: Spontaneously aborted women are suffered from significant decrease of serum total 25-hydroxyvitamin D level and that vitamin deficiency was more overt and significant in women with recurrences of abortion suggesting that vitamin D deficiency might be a modifiable risk factor for spontaneous abortion.[Full Text Article]