WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Sunil Mishra, Sangeeta Singh and Ashutosh Yadav

ABSTRACT

Insomnia refers the problem with sleep duration or quality, as well as difficulties initiating or sustaining sleep, are common symptoms, as can significantly distress and impairments in daytime functioning. this research focuses on pharmacological screening of hypnotic effect of hydroalcoholic leaves extract (HLE) of Bacopa monnieri (Brahmi) in Wistar albino rats by using diverse types of animal models to confirm its actual pharmacological potential. Leaves of Bacopa monnieri (Brahmi) were obtained from the Unnao reason. It was identified and authenticated by a botanist. The leaves were washed making dust-free and dried at room temperature or shade. The dried leaves are rendered into coarse powders and then finally into fine ones and extracted separately into 3 solvents i.e., distilled water, ethanol and methanol using percolator. Rats were divided into group 1 (normal saline), group 2 (Diazepam 4mg/kg), group 3a & 3b (Aq. BM leaves extract- 80mg/kg & 120mg/kg), group 4a & 4b (Eth. BM leaves extract- 80mg/kg & 120mg/kg) and group 5a & 5b (Meth. BM leaves extract- 80mg/kg & 120mg/kg). Several parameters were estimated as Thiopental sodium-induced sleeping time estimation, Motor co-ordination (Rota-rod) test, Light-Dark Arena Model and Locomotion Activity. In results, it confirmed that BM is much significant in the preclinical treatment of insomnia and related issues. Its mode of action may be suppression of neurotransmitters release, increase the destruction of catecholamines. In conclusion, leaves of BM are efficacious in the subsiding the insomnia and reset mind to induce sleep. It suggests to isolate the significant active component towards the activity and convert into suitable dosage for better absorption and tolerability.

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