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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
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HYPOGLYCEMIC EFFECT OF ‘PORANG’ FLOUR (Amorphophallusmuellery Blume) ON HYPERGLYCEMIC RATS AND IN SILICO PHARMACODYNAMICS ANALYSIS
Novita Dewi*, Karyono Mintaroem, Moch Muljohadi Ali, Hidayat Suyuti, Hani Susianti
Background: An acute hyperglycemia is a life-threatening emergency, occurring in patients with plasma glucose more than 600 mg/dL. Hyperglycemia could be managed by lowering blood plasma glucose.Porang bulb (AmorphophallusmuelleriBlume) is expected to have a hypoglycemic effect on hyperglycemic rats, and there is no in-silico mechanism explaining the process. This study aimed to investigate the hypoglycemic effect of Porang flour (AmorphophallusmuelleriBlume) in hyperglycemic rats and its in-silico pharmacodynamics analysis. Methods: The study was performed on25 hyperglycemic rats with the pre-post test only control group design. Rats was divided equally in five groups, namely normal group (K), hyperglycemic group (K+), Porang flour treatment group with dose 100 mg/kgBW (P1), Porang flour treatment group with dose 200 mg/kgBW (P2), and Porang flour treatment group with dose 400 mg/kgBW (P3).Induction of hyperglycemia was performed with 60% high fructose diet and intraperitoneal STZ injection with dose 25 mg and 30 mg. We measured pre test blood glucose. The insilico instruments used werepubchem and molinspiration, icd lab, string and stitch, pymol, and pyryx.The data were analyzed usingt test (p<0.05). Results: results showed the treatment of porang meal contributes significantly to the average GDP. There are two mechanism action of glucomannan (non-receptor) and action of Metabolite glucomannan (acetate, butyrate, propionate) (receptor). Conclusions: These findings different results effects of porang flour in hyperglycemic rats and pharmacodynamic analysis in insilico metabolite glucomannan had an unequal mechanism of action with hypoglycemic agent metformin, possibly another more influential mechanism.[Full Text Article]