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IMMUNOREGULATORY EFFECTS OF THE AQUEOUS EXTRACT OF THE BARK DISTEMONANTHUS BENTHAMIANUS BAILL. (CAESALPINIACEAE: LEGUMINOSAE - CAESALPINIOIDEAE) ON ANEMIA IN RATS WISTAR INDUCED BY PHENYHYDRAZIN
Kouadio K. J.*, Ouattara-Soro F. S., Yao K. B. and Abizi G.
Background: Distemonanthus benthamianus is a plant commonly used in traditional African pharmacopoeia to treat several inflammatory problems, and pains. It is also used in cases of blood disorders during infections. The objective of the present work is to evaluate, on white rats of wistar strain, the anti- anemic property of the aqueous extract of the barks of D. benthamianus. Material and Methods: Laboratory animals were randomly grouped into six groups of five rats each. Phenylhydrazin (PHZ) was administered twice at 40 mg/kg/bw to induce hemolytic anemia. Blood samples were taken on day D0, D2, D7, D14, D21 to follow the evolution of blood parameters. Results: Administration of PHZ to the animals significantly decreased the red blood cell count, hemoglobin concentration and hematocrit level (a reduction of about 35% of the parameters). Administration of the plant extract to PHZ-induced anemic rats induced the increase of red blood cell count (14.3%), hemoglobin (37.12) and hematocrit (66.16%) on the seventh day of treatment. A significant decrease (p ?0.05) in the body weight of the rats was observed, however an increase in the relative weights of the kidneys, liver, spleen, thymus of the untreated anemic rats was observed compared to the healthy rats and anemic rats treated with the extract there. Conclusion: This study shows that Distemonanthus benthamianus effectively improves the hematological parameters of anemic rats. It would therefore be a powerful remedy against anemia, however additional studies must be done to find the ideal fraction or the molecule responsible for this activity.[Full Text Article]