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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
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OXYGEN CONTAINING HETEROCYCLIC SCAFFOLDS AS ANTICANCER AGENT- A REVIEW
Kiranbir Kaur*, Sharanjit Kaur, Varinder Soni*, Sandeep Rahar and Komalpreet Kaur
A cancer is a devastating problem which is depicted by the uncontrolled development and spread of abnormal cells by invasion and metastasis. According to world health organization (WHO), more than 80% of world’s population relies on traditional medicines for their essential health care needs. Numerous naturally occurring compounds containing oxygen heterocycles, shows fascinating therapeutic activities. Oxygen containing heterocyclic compounds, present in most pharmaceuticals is currently marketed. A variety of Oxygen containing heterocyclic compounds showed anti-inflammatory, analgesic, neuroprotective, anti-hypertensive, anti-anxiolytic, anti-arrythmic, and prominent anti-tumour activities. Mostly drugs having oxygen heterocycles, found in the most abundant class of these anti-cancerous drugs. The oxygen containing heterocyclic compounds like benzopyran, coumarins, flavonoids, furans, pyrans, showed cytotoxic effects against various cancer cell lines viz; MCF-7, HeLa, MDA-MB-231, MCF-10A, OVCAR-3, PC-3, A-549. The studies also suggested that a non-aromatic ring can greatly affect the anti-tumour activity and cancer cell line selectivity.[Full Text Article]