WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

ISSN 2457-0400

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

OXYGEN CONTAINING HETEROCYCLIC SCAFFOLDS AS ANTICANCER AGENT- A REVIEW

Kiranbir Kaur*, Sharanjit Kaur, Varinder Soni*, Sandeep Rahar and Komalpreet Kaur

ABSTRACT

A cancer is a devastating problem which is depicted by the uncontrolled development and spread of abnormal cells by invasion and metastasis. According to world health organization (WHO), more than 80% of world’s population relies on traditional medicines for their essential health care needs. Numerous naturally occurring compounds containing oxygen heterocycles, shows fascinating therapeutic activities. Oxygen containing heterocyclic compounds, present in most pharmaceuticals is currently marketed. A variety of Oxygen containing heterocyclic compounds showed anti-inflammatory, analgesic, neuroprotective, anti-hypertensive, anti-anxiolytic, anti-arrythmic, and prominent anti-tumour activities. Mostly drugs having oxygen heterocycles, found in the most abundant class of these anti-cancerous drugs. The oxygen containing heterocyclic compounds like benzopyran, coumarins, flavonoids, furans, pyrans, showed cytotoxic effects against various cancer cell lines viz; MCF-7, HeLa, MDA-MB-231, MCF-10A, OVCAR-3, PC-3, A-549. The studies also suggested that a non-aromatic ring can greatly affect the anti-tumour activity and cancer cell line selectivity.

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