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Best Article of current issue
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PREVALENCE OF INVASIVE DUCTAL BREAST CARCINOMA SUBTYPES AND ITS ASSOCIATION WITH STAGE, GRADE AND IMMUNE HISTOCHEMISTRY
*Dr. Yasameen Emad Mahmood and Dr. Nazar Abdulhassan Alwakeel
Introduction: Breast cancer is considered the most important and common cancer worldwide and cause high mortality rate (second cause of death). Breast cancer incidence become high in last decade. Carcinoma of breast classified into five subgroups according to appearance of gene by use DNA microarray. The aim of this study was to recognize and describe the detailed occurrence of molecular subtypes of invasive carcinoma of breast by using immunohistochemistry (IHC) and to associate with the morphological structures and predictive factors. Method: A cross sectional study of hundred patients with primary invasive breast ductal carcinoma that were collected from the archive of the teaching laboratories in Baghdad medical city, Baghdad, Iraq. In the period from June 2018 to May 2021. Where the variables taken; age and gender of patients, stage T, N and grade of breast carcinoma. Also PR, ER and HER2neu were taken for each patients. Results: mean age (51.51 ± 12) years old, 32% and 30% of patients at age groups 40-49 years old and 50-59 years old respectively, 98% of patients are females and there is 2% males in this study, (50%) of patients at stage T 2, 31% of patients at stage N1, (61%) of patients at grade 2 of cancer development, (65%, 64%, 24%) of patients have ER, PR, HER2neu respectively, 81% of patients diagnosed histopathological as NOS, 6% as metaplastic and 5% as medullary. There is significant association between grading, ER, PR and histopathological diagnosis. Conclusion: Most common histopathological type of invasive ductal breast cancer is NOS. Medullary, metaplastic and micro papillary types found at grade 3. Most patients with NOS and papillary histopathological type found at grade 2. All of patients diagnosed as mucinous and papillary carcinoma with positive ER, and all of patients diagnosed as mucinous and papillary with positive PR.[Full Text Article]