WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

News & Updation

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in WJAHR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • WJAHR New Impact Factor

    Its our Pleasure to Inform you that WJAHR Impact Factor has been increased from  4.897 to 5.464 due to high quality Publication at International Level

  • .

    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

  • New Issue Published

    Its Our pleasure to inform you that, WJAHR February 2023 Issue has been Published, Kindly check it on https://www.wjahr.com/home/current_issues

  • WJAHR: FEBRUARY ISSUE PUBLISHED

    FEBRUARY 2023 Issue has been successfully launched on 1 February 2023.

Best Paper Awards

World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.

Best Article of current issue

Download Article : Click here

Indexing

Abstract

AN UPDATE ON THE THERAPEUTIC POTENTIAL OF HERBAL PREPARATIONS WITH REGARDS TO MOLECULAR & BIOCHEMICAL MECHANISMS IN THE MANAGEMENT OF DIABETES MELLITUS: A SYSTEMATIC REVIEW

*Dr. Kulvinder Kochar Kaur, Dr. Gautam Allahbadia and Dr. Mandeep Singh

ABSTRACT

Evaluation of Diabetesmellitus (DM)kinds has demonstrated significant patterns. Of these the ones of maximum importance are inclusive of Oxidative stress,inflammation in addition to cellular demise .Till date drug treatments for DM are not optimal,hence need for innovative therapy has assumed great significance that is key for trying to discover the same. In the past decades medicinal plants have got thoroughly explored as well as their utilization is being escalatingly done in the form of alternative ones as natural product s with the idea of curing the disease. We had reviewed various phytochemical therapiesearlier that were inclusive of Dietary polyphenols, like resveratrol,curcumin, proteintyrosine phosphatase1 B (PTP1B) inhibitors, plant terpenes (specifically monoterpenes), flavonoids (quercetin, kaempherol), ursolic acid, besides epigenetic modes of certain plant agents. Our aim was to extensively evaluate the modes of biochemical actions in control of DM, to be able to utilize them clinically. Here we conducted a systematic review utilizing search engine pubmed, google scholar; web of science; embase; Cochrane review library utilizing the MeSH terms likeDM; Plant preparations from Nigella Sativa(NS); Berberine(Ber); curcumin(CUR); Moringa Olifera(MO); Portulaca Oleracea(PO); Punica Granatum(PG); typeIIID Mor Alzheimer’sdisease; 5’AMP-activatedprotein kinase(AMPK); STAT3, PI3K/Akt; PTP1BInhibiors; IRS1;2; NADPH Oxidase; AGE; RAGE; NF?B,; proinflammatory cytokines; COVID19 from 2010 till date. Although main idea was to include human studies, we did include animal studies for validation of biochemical mode to help in their utilization with oral hypoglycaemic agents infuture if not alone. We found a total of 3600 articles out of which we selected 168 articles for this review. No meta-analysis was done. It was observd that most of these 6 major plants studied(NS,Ber, CUR, MO, PO, PG,targeted 5’(adenosine monophosphate (AMP)-activated protein kinase(AMPK) actionthat was followed by down stream actions of ACC,Akt as well as PI3K by which they ameliorated the disease. Thus with least toxicity, economical, easy access it is warranted to get over whatever bioavailability, problems we have faced with drugs like curcumin sothat they can get easily used singly or for reduction of oral antidiabetics.

[Full Text Article]