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AN UPDATE ON THE THERAPEUTIC POTENTIAL OF HERBAL PREPARATIONS WITH REGARDS TO MOLECULAR & BIOCHEMICAL MECHANISMS IN THE MANAGEMENT OF DIABETES MELLITUS: A SYSTEMATIC REVIEW
*Dr. Kulvinder Kochar Kaur, Dr. Gautam Allahbadia and Dr. Mandeep Singh
Evaluation of Diabetesmellitus (DM)kinds has demonstrated significant patterns. Of these the ones of maximum importance are inclusive of Oxidative stress,inflammation in addition to cellular demise .Till date drug treatments for DM are not optimal,hence need for innovative therapy has assumed great significance that is key for trying to discover the same. In the past decades medicinal plants have got thoroughly explored as well as their utilization is being escalatingly done in the form of alternative ones as natural product s with the idea of curing the disease. We had reviewed various phytochemical therapiesearlier that were inclusive of Dietary polyphenols, like resveratrol,curcumin, proteintyrosine phosphatase1 B (PTP1B) inhibitors, plant terpenes (specifically monoterpenes), flavonoids (quercetin, kaempherol), ursolic acid, besides epigenetic modes of certain plant agents. Our aim was to extensively evaluate the modes of biochemical actions in control of DM, to be able to utilize them clinically. Here we conducted a systematic review utilizing search engine pubmed, google scholar; web of science; embase; Cochrane review library utilizing the MeSH terms likeDM; Plant preparations from Nigella Sativa(NS); Berberine(Ber); curcumin(CUR); Moringa Olifera(MO); Portulaca Oleracea(PO); Punica Granatum(PG); typeIIID Mor Alzheimer’sdisease; 5’AMP-activatedprotein kinase(AMPK); STAT3, PI3K/Akt; PTP1BInhibiors; IRS1;2; NADPH Oxidase; AGE; RAGE; NF?B,; proinflammatory cytokines; COVID19 from 2010 till date. Although main idea was to include human studies, we did include animal studies for validation of biochemical mode to help in their utilization with oral hypoglycaemic agents infuture if not alone. We found a total of 3600 articles out of which we selected 168 articles for this review. No meta-analysis was done. It was observd that most of these 6 major plants studied(NS,Ber, CUR, MO, PO, PG,targeted 5’(adenosine monophosphate (AMP)-activated protein kinase(AMPK) actionthat was followed by down stream actions of ACC,Akt as well as PI3K by which they ameliorated the disease. Thus with least toxicity, economical, easy access it is warranted to get over whatever bioavailability, problems we have faced with drugs like curcumin sothat they can get easily used singly or for reduction of oral antidiabetics.[Full Text Article]