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Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
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Abstract
SYSTEMIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA: A CASE REPORT OF AN ASYMPTOMATIC PATIENT FROM SYRIA
Lujain Hamdan*, Souliman Diab, Zuheir Al-Shehabi and Michael Georgeos
ABSTRACT
Anaplastic large cell lymphomas (ALCLs) are uncommon malignancies; they include a group of CD30-positive Non-Hodgkin T-cell lymphomas that share similar morphologic and immunophenotypic features. The World Health Organization identifies 3 entities: primary cutaneous ALCL, anaplastic lymphoma kinase (ALK)-positive ALCL, and ALK-negative ALCL. ALK-negative ALCL is known for its aggressive behaviour and poor prognosis. It usually affects males at a median age of 55-60 years old. The majority of patients are presented with B symptoms and stage III–IV of the disease. Medical literature has reported very few cases of systemic ALK-negative ALCL. Here we demonstrate a unique case of a 47-year-old male, with no systemic symptoms, diagnosed with a stage IV, CD30+, ALK-negative ALCL presented with several tender, enlarged, inguinal lymph nodes and extranodal involvement in the skin, lung, liver and the bone marrow.
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