WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Simeon Kayowa Olatunde*, Isaac Oluwasogo Amao, Shauna Angella Ebanks, Grace Mosunmola Adegbola, Rebecca Richard

ABSTRACT

Misfolded proteins which have the ability to pass on their misfolded form to regular variants of the same protein are defined as Prions. They are associated with a number of lethal and transmissible neurodegenerative diseases in humans and many other species. The two-step process by which information in genes is converted into proteins is explained by the fundamental dogma of molecular biology. Similarly, Lamarckian inheritance claims that an organism has the ability to pass on physical characteristics acquired by the parent organism to its offspring during its lifetime. There is an exception or limitation to these theories. The genetic properties incorporated in prions established the causes of central Dogma theory violation, this occurrence appears to be a distinctive phenomenon and consequently stimulating a genetic mutation as the case may be. This critical review attempt to provide an insight to factual existence of Prions, Definitions, Functions, hypothesis of misfolded proteins, why Central Dogma theory (CDT) need to be revisit, Limitations to CDT, Factors responsible for limitations and challenges.